Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Methyl-1H-pyrazol-3-amine
2-Bromo-5-fluoropyridine (1) (1 .Og, 5.71 mmcl), 1-methyl-I H-pyrazol-3-amine (2) (554mg, 5.7Immol), Xantphos (0.33g, 0.57mmol), and Cs2003 (2.79g, 8.56mmol) were combined in dry 1,4-dioxane (I5mL). The reaction mixture was degassed with N2(g) and placed under vacuum for 10mm. Pd2(dba)3 (0.26g,0.28mmol) was then added and the resulting reaction mixture was heated at90°C for 30h. It was then poured onto demineralized water (200mL), and extracted with EtOAc (3 x IOOmL). The organic phases were combined, dried over Na2SO4, filtered and subsequently evaporated under vacuum. The resulting residue was purified by flash chromatography, eluting with EtOAc/Hexane (1:1)to provide 5-fluoro-N-(1-methyl-IH-pyrazol-3-yl)pyridin-2-amine (3) as a yellow solid (0.65g, 61percent).LCMS (ES): Found 193.0 [MH]+.
The synthetic route of 1904-31-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KARUS THERAPEUTICS LTD; SHUTTLEWORTH, Stephen Joseph; TOMASSI, Cyrille Davy; CECIL, Alexander Richard Liam; MACCORMICK, Somhairle; NODES, William John; SILVA, Franck Alexandre; WO2014/72714; (2014); A1;,
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