Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17635-45-9, name is 4-Pyrazol-1-yl-phenylamine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Pyrazol-1-yl-phenylamine
General procedure: A mixture of aniline derivative 1a?1e (1 mmol) and 1 cm3concentrated hydrochloric acid was thoroughly stirred atroom temperature for 15 min and then cooled to 0 C. Asolution containing 0.069 g sodium nitrite (1 mmol) in 10 cm3 water was added dropwise to the initial mixtureduring 40 min. An aqueous solution of aromatic nucleophile(1 mmol) in NaOH 10percent (5 cm3) was then addedand the resulted mixture was stirred for 1 h at 0 C. Theprecipitated solid was filtered, washed with water and dried in air. The products 2a?2c, 2e, 2f, 2m, and 2o were purifiedby recrystallization in ethanol, but preparative TLC (nhexane?EtOAc, 4:1) was applied for purification of products2d, 2g?2l, 2n, and 2p.
According to the analysis of related databases, 17635-45-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Ghasemi, Zarrin; Azizi, Sajjad; Salehi, Roya; Kafil, Hossein Samadi; Monatshefte fur Chemie; vol. 149; 1; (2018); p. 149 – 157;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics