Synthetic Route of 78703-53-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 78703-53-4, name is 1,3-Dimethyl-1H-pyrazole-4-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
100 mL with spherical condenserA 1-dimethyl-1H-pyrazole-4-carboxylic acid (7.5 mmol) intermediate was added to a single-necked round bottom flask followed by the addition of 30 mmol of thionyl chloride under stirring. After refluxing for 4 hours, To give 1-methyl-3-methyl-1H-pyrazole-4-acid chloride (V)In step 2), the chlorinating reagent is one or more mixture of thionyl chloride, phosphorus oxychloride or phosphorus trichloride.
The synthetic route of 1,3-Dimethyl-1H-pyrazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang University of Technology; Liu Xinghai; Zhao Wen; Shen Zhonghua; Peng Weili; Tan Chengxia; Weng Jianquan; (11 pag.)CN106632044; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics