Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1203705-55-8, name is 3-Bromo-1H-pyrazol-5-amine, A new synthetic method of this compound is introduced below., Quality Control of 3-Bromo-1H-pyrazol-5-amine
A mixture of methyl 2-hydroxy-4-oxo-4-(pyridin-2-yl)but-2-enoate [1224740-13-9] (730 mg, 3.52 mmol) and 3-bromo-lH-pyrazol-5-amine [950739-21-6] (628 mg, 3.88 mmol) in MeOH (17 mL) was stirred under reflux for 18 h. The reaction mixture was cooled to rt and the precipitate was filtered off, rinsed with MeOH and dried. The residue (546 mg) was purified via achiral SFC (Stationary phase: Lux Cellulose-2 5 pm 250*30mm, mobile phase: 60% C02, 40% MeOH) to afford intermediate 1171 (147 mg, 13%) as a yellow solid.
The synthetic route of 1203705-55-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN SCIENCES IRELAND UNLIMITED COMPANY; LANCOIS, David Francis Alain; GUILLEMONT, Jerome Emile Georges; RABOISSON, Pierre Jean-Marie Bernard; ROYMANS, Dirk Andre Emmy; RIGAUX, Peter; MICHAUT, Antoine Benjamin; MERCEY, Guillaume Jean Maurice; (295 pag.)WO2019/106004; (2019); A1;,
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