Adding a certain compound to certain chemical reactions, such as: 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 368870-03-5, HPLC of Formula: C10H11N3
A solution of ethyl 2-(bromomethyl)-6-methoxybenzoate (0.50 g), (4-(1H-pyrazol-1-yl)phenyl)methanamine (0.32 g) and potassium carbonate (0.38 g) in ethanol (5 mL) was stirred under a nitrogen atmosphere at room temperature overnight. To the reaction solution was added water, and the resulting precipitate was collected by filtration, and dried. To the obtained white solid was added 25% hydrobromic acid (acetic acid solution) (5 mL), and the mixture was stirred under a nitrogen atmosphere at 120C overnight. The reaction solution was neutralized with saturated aqueous sodium hydrogen carbonate solution, and ethyl acetate was added. The organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by NH silica gel chromatography (hexane-ethyl acetate) to give the title compound (0.31 g). 1H NMR (300 MHz, DMSO-d6) delta 4.31 (2H, s), 4.69 (2H, s), 6.48-6.58 (1H, m), 6.82 (1H, d, J = 8.3 Hz), 6.94 (1H, d, J = 7.6 Hz), 7.30-7.44 (3H, m), 7.73 (1H, d, J = 1.3 Hz), 7.82 (2H, d, J = 8.7 Hz), 8.46 (1H, d, J = 2.3 Hz), 9.63 (1H, brs).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-(1H-Pyrazol-1-yl)phenyl)methanamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Takeda Pharmaceutical Company Limited; SUGIMOTO, Takahiro; NAKAMURA, Minoru; SAKAMOTO, Hiroki; SUZUKI, Shinkichi; YAMADA, Masami; KAMATA, Makoto; KOJIMA, Takuto; FUJIMORI, Ikuo; SHIMOKAWA, Kenichiro; EP2921480; (2015); A1;,
Pyrazole – Wikipedia,
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