Adding a certain compound to certain chemical reactions, such as: 28466-26-4, name is 4-Aminopyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 28466-26-4, COA of Formula: C3H5N3
General procedure: Different five-membered heterocyclic amines (1.72 mmol) and sodiumcarbonate (0.36 g, 3.44 mmol) were added to anhydrous tetrahydrofuran(10 mL) at 0 C. Then, 15b (0.35 g, 1.72 mmol) dissolved in5 mL of tetrahydrofuran was added. Stirring was continued for an additional1 h in the ice bath (monitored by TLC). The organic phase wasfiltered and the diethyl ether (10 mL) was added to the filtrate. Finally,the solid was precipitated from the filtrate to afford the intermediates16i-k. 4.1.6.1. 2-bromo-N-(1H-pyrazol-4-yl)acetamide (16i). The crude 16iwas used directly in the next step without further purification
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Reference:
Review; Wang, Zhao; Yu, Zhao; Kang, Dongwei; Zhang, Jian; Tian, Ye; Daelemans, Dirk; De Clercq, Erik; Pannecouque, Christophe; Zhan, Peng; Liu, Xinyong; Bioorganic and Medicinal Chemistry; vol. 27; 3; (2019); p. 447 – 456;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics