Application of 124004-31-5, The chemical industry reduces the impact on the environment during synthesis 124004-31-5, name is 5-Amino-1H-pyrazole-3-carboxylic acid, I believe this compound will play a more active role in future production and life.
General procedure: The corresponding amino acid2, 4 (0.0173 mol) was dissolved in 2 aqueous l (50 ml),and the formed solution was cooled to 0 in an ice bath.Aqueous NaNO2 (0.019 mol) was dropwise added to thereaction mixture. The mixture was stirred for 30 min, thenaqueous NaN3 (0.026 mol) was carefully added. Thereaction mixture was stirred for 3-4 h. The formed precipitatewas filtered off on a fritted glass filter and washed witha small amount of H2O, then dried in a vacuum desiccatorover P2O5 to constant weight. The filtrate was extractedwith EtOAc, the organic phase was separated and driedover anhydrous Na2SO4. The dried organic phase wasevaporated under reduced pressure on the rotary evaporatorto afford a solid. Both solids were combined.5-Azido-1-pyrazole-3-carboxylic acid (5). Yield 2.32 g(87%), yellow solid, mp 164-165. IR spectrum, nu, cm-1:3309 (NH), 3101 (OH), 2125 (N3), 1675 (C=O). 1H NMRspectrum (400 MHz, DMSO-d6), delta, ppm: 13.76 (2, br. s,NH, COOH); 6.48 (1H, s, -4 pyrazole). 13C NMRspectrum (101 MHz, DMSO-d6), delta, ppm: 160.3; 147.6;136.9; 98.9. Found, m/z: 154.0363 [M+H]+. C4H4N5O2.Calculated, m/z: 154.0360. Found, %: C 31.51; H 1.82;N 45.37. 4H3N5O2. Calculated, %: C 31.38; H 1.98;N 45.74.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-1H-pyrazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Dalinger, Aleksander I.; Medved?ko, Alexey V.; Balalaeva, Alexandra I.; Vatsadze, Irina ?.; Dalinger, Igor L.; Vatsadze, Sergey Z.; Chemistry of Heterocyclic Compounds; vol. 56; 2; (2020); p. 180 – 191;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics