Synthetic Route of 1280210-79-8,Some common heterocyclic compound, 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, molecular formula is C10H15N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred 0 C solution of tert-butyl 4,6- dihydropyrrolo[3 ,4-c]pyrazole-5 (2H)-carboxylate (100.00 mg, 0.48 mmol) was added lithium bis(trimethylsilyl)amide (1.00 mL, 1.00 mmol) in THF. The mixture was stirred at 0C for 30 mi 2,2-Dimethyloxirane ( 0.29 mL, 2.39 mmol) was added and the mixture was stirred at rt for 3 h and heated to 80 C for 2 h under microwave irradiation. The crude material was diluted with EtOAc, washed with brine (3 x 30 mL), and concentrated under reduced pressure to a yellow oil. The yellow oil was absorbed onto silica and purified (FCC, Si02, 30-70% EtOAc:hexanes) to afford a 1:1 mixture of the title compounds: tert-butyl 2-(2-hydroxy-2-methylpropyl)-4,6-dihydropyrrolo [3,4-c]pyrazole-5(2H)-carboxylate and tenbutyl 1 -(2-hydroxy-2-methylpropyl)-4,6-dihydropyrrolo [3 ,4-c]pyrazole-5 (1 H)-carboxylate (70 mg, 52%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, its application will become more common.
Reference:
Patent; DART NEUROSCIENCE, LLC; BASINGER, Jillian; BOOKSER, Brett; CHEN, Mi; CHUNG, DeMichael; GUPTA, Varsha; HUDSON, Andrew; KAPLAN, Alan; NA, James; RENICK, Joel; SANTORA, Vincent; WO2015/164520; (2015); A1;,
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