In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89179-62-4, name is 1-Methyl-1H-pyrazole-3-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 89179-62-4
To a solution of 1-methyl-1H-pyrazole-3-carboxamide (400 mg, 3.2 mmol) in dioxane (30mL) was added LAH (365 mg, 9.6 mmol). The resulting mixture was stirred for 3 h at 100°C.After it was cooled to 0°C, it was quenched with 0.4 ml water, 0.4 mL 15percent NaOH aqueous, 1.2mL water in tum. Anhydrous sodium sulfate was added to the solution. The mixture was filteredand concentrated to give the crude product which was used for the next step directly.
The synthetic route of 89179-62-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott D.; MCCOMAS, Casey C.; REGER, Thomas S.; QI, Changhe; WO2014/139150; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics