In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5334-39-4 as follows. Formula: C4H5N3O2
(a) tert-Butyl 3-methyl-4-nitro- 1H-pyrazole- 1-carboxylate or tert-butyl 5-methyl-4- nitro- 1H-pyrazole- 1-carboxylate (A25)Di-tert-butyl dicarbonate (5.15 g, 23.6 mmol) and 4-dimethylaminopyridine (0.481 g, 3.93 mmol) were added to a solution of 3-methyl-4-nitropyrazole (2.50 g, 19.7 mmol)in DCM (100 mL) and the mixture was stirred at room temperature for 16 hours. The reaction mixture was washed with water (100 mL), brine (100 mL), dried (phase separator) and concentrated under reduced pressure. The residue was adsorbed onto Si02 and purified by column chromatography (Biotage Isolera, 2 x 40 g Si02 cartridges, 0-50% EtOAc in petroleum benzine 40-60 00) to give the title compoundA25 as a white solid (2.54 g, 57%). LCMS-D: rt 3.39 mm; no product ion detected.
According to the analysis of related databases, 5334-39-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CANCER THERAPEUTICS CRC PTY LIMITED; FOITZIK, Richard Charles; MORROW, Benjamin Joseph; HEMLEY, Catherine Fae; LUNNISS, Gillian Elizabeth; CAMERINO, Michelle Ang; GANAME, Danny; STUPPLE, Paul Anthony; LESSENE, Romina; KERSTEN, Wilhelmus Johannes Antonius; HARVEY, Andrew John; HOLMES, Ian Peter; WO2014/26243; (2014); A1;,
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