Synthetic Route of 5334-39-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a mixture of 3-methyl-4-nitro-lH-pyrazole (5 g, 39.34 mmol) and tetrahydropyran-4-ol (4.82 g, 47.21 mmol, 4.73 mL) in THF (70 mL) was added PI3 (15.48 g, 59.01 mmol) and DIAD (11.93 g, 59.01 mmol . 1.47 mL) in one portion at 0C under N2. The mixture was stirred at 0 C for 60 min, then warmed to 25 C and stirred for 16 h. The mixture was poured into the mixture of PE and EtOAc (PE:Ei()Ac = 1 : 1) (100 mL), filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc = 5: 1) to afford 5- methyl-4-iiitro-l-tetrahydropyran-4-yl-pyrazole and 3-methyl-4-nitro~l -tetrahydro-2H~pyran~4-yl~ pyrazole as yellow solids. LCMS: RT 0.610 min, m/z = 212.2 [M+H]
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methyl-4-nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DENALI THERAPEUTICS INC.; ESTRADA, Anthony A.; FENG, Jianwen A.; LYSSIKATOS, Joseph P.; SWEENEY, Zachary K.; DE VICENTE FIDALGO, Javier; (271 pag.)WO2017/87905; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics