Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1082745-50-3, name is 5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H14N4O2
To the mixture of 5-amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide (Intermediate P6, 0,301 g, 1,55 mmol) and ethyl (2-chlorophenoxy)-acetate (Intermediate P16, 1.663 g, 7.75 mmol) in dry tetrahydrofuran (16 mL) 5 eq. of IM soLution of potassium tert-butanolate in tetrahydrofuran were addedand the whole was heated at reflux for 18 hours. The crude product was isoLated by extraction with ethyl acetate, organic layer was washed with brine and dried with sodium sulphate. The compound was purified by chromatography on silica gel (hexane/acetone, gradient from 100:0 to 0:100). 95 mg of the titLe product were obtained as an amorphous soLid (yield 29.2%).1H NMR (300MHz, DMSO-d6): delta 12.37(5, 1H), 8.09 (s, 1H), 7.47 (m, 1H), 7.31 (m,1H), 7.25 (m, 1H), 7.01 (m, 1H), 5.14 (s, 2H), 4.87 (m, 1H), 3.94 (m, 2H), 3.47 (m, 2H), 2.09 (m, 2H), 1.77 (m, 2H).MS-ESI: (m/z) calculated for C17H18C1N4O3 [M+H]+: 361 .79, found 361 .8.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CELON PHARMA S.A.; MOSZCZY?SKI-P?TKOWSKI, Rafa?; BOJARSKI, ?ukasz; STEFANIAK, Filip; WIECZOREK, Maciej; DUBIEL, Krzysztof; LAMPARSKA-PRZYBYSZ, Monika; WO2014/16789; (2014); A1;,
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