In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 162758-35-2, name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: pyrazoles-derivatives
To a stirred solution of compound 2 (382 mg; 1.0 mmol) in toluene (10 ml) one drop of dimethyl formamide was added. The reaction mixture was cooled to 0 C and added thionyl chloride (140 mg:1 .2mmol) in 2ml toluene drop-wise for the period of 2 minutes at the same temperature. The reaction mixture was allowed to attain room temperature and heated at 100 C for 4 h. Excess of thionyl chloride and toluene was distilled off under reduced pressure. In another flask under nitrogen atmosphere was introduced 1- amino piperidine (100 mg; 1.0 mmol) and triethyl amine (101 mg; 1.0 mmol) in 5.0 ml dichloromethane. The flask was cooled to 0 C. To this was added a cooled solutionof acid chloride drop-wise at the same temperature. The resulting reaction mixture was allowed to attain room temperature and then it was stirred for 12 h. After completion of the reaction (monitored by TLC), the reaction mixture was diluted with water (10 ml) and organic layer was separated, washed with water (2 x 5 ml) and brine solution(5m1), dried over Na2SO4(anhydrous) and concentrated in vacuo. The residue was purified by column chromatography over silica gel (ethyl acetate/petroleumether 1:9(v/v)) afforded pure product.
The synthetic route of 162758-35-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; GAJBHIYE, Jayant, Maroti; WO2014/174457; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics