Related Products of 128694-63-3, A common heterocyclic compound, 128694-63-3, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid, molecular formula is C6H5F3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a suspension of 6-(2-amino-5-chlorothiazol-4- yl)-3,4-dihydroquinolin-2(1H)-one (0.100 g, 0.41 mmol) and 1 -methyl-3-(trifluoromethyl)- 1 H-pyrazole-5-carboxylic acid (0.087 g, 0.45 mmol), and pyridine (0.16 m E, 1.96 mmol) in acetonitrile (2.5 mE) in a sealed tube was added propylphosphonic anhydride solution (50 wt % in ethyl acetate, 0.61 mE, 1.02 mmol). The sealed tube was heated to 1000 C. for 16 hand the precipitation formed. Afier cooling, 1 -methyl-N-(4-(2-oxo-i ,2,3,4-tetrahydroquinolin-6-yl)thi- azol-2-yl)-3-(trifluoromethyl)-i H-pyrazole-5-carboxamide (0.160g, 93%). ?H NMR (400 MHz, DMSO-d): oe 12.97(bs, 1H), 10.20 (s, 1H), 7.74 (m, 1H), 7.71 (m, 1H), 7.59 (s, 1H),6.91 (d, 1H, J=8.0 Hz), 4.23 (s, 3H), 2.93 (t, 2H, J=7.2 Hz),2.48 (partial masked under d-DMSO, m, 2H); MS (ESI):Calcd. for C,8H,4F3N5025: 421, found 422 (M+i).
The synthetic route of 128694-63-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nantbio, Inc.; Tao, Chunlin; Nallan, Laxman; Ho, David G.; Wang, Qinwei; Weingarten, Paul; Juncker-Jensen, Anna B.; (121 pag.)US2018/201610; (2018); A1;,
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