In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 143426-49-7, name is (4-Pyrazol-1-yl-phenyl)methanol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C10H10N2O
To a solution of l-(4-hydroxymethylphenyl)-lH-pyrazole (1.0 g, 0.005 mole) in DCM (25 mL) at 0 C under N2, was added phosphorus tribromide (0.64 mL, 0.0068 mole) drop wise. Reaction mixture was warmed to RT and stirred for 2 h. The reaction mixture was diluted with DCM (75 mL), treated with saturated aqueous sodium bicarbonate (20 mL). Organic layer was washed with water (30 mL), brine solution (30 mL) and dried over Na2S04 and concentrated under vacuum to obtain the title compound. (0227) Yield: 1.25 g; 1H – NMR (DMSO -d6, 400 MHz) d ppm: 4.76 (s, 2H), 6.55 (s, 1H), 7.56 – 7.58 (d, J = 8.5 Hz, 2H), 7.75 (s, 1H), 7.82 – 7.84 (d, J = 8.4 Hz, 2H), 8.51 – 8.52 (d, J = 2.4 Hz, 1H); Mass (m/z): 236.9 (M+H)+, 239 (M+H)+.
The synthetic route of 143426-49-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUVEN LIFE SCIENCES LIMITED; NIROGI, Ramakrishna; SHINDE, Anil Karbhari; MOHAMMED, Abdul Rasheed; BADANGE, Rajesh Kumar; PALACHARLA, Raghava Choudary; JASTI, Venkateswarlu; (61 pag.)WO2019/102365; (2019); A1;,
Pyrazole – Wikipedia,
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