The important role of 40711-33-9

Electric Literature of 40711-33-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 40711-33-9, name is Ethyl 5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of ethyl 5-oxo-2,5-dihydro-1 H-pyrazole-3-carboxylate (0.6 g, 3.84 mmol, which may be prepared as described in Synthesis 2003, 15, 2353-2357), 1 ,1- dimethylethyl 4-hydroxy-1-piperidinecarboxylate (1.160 g, 5.76 mmol) and TPP (1.774 g, 6.76 mmol) in THF (8.4 ml), at 0 0C and under a nitrogen atmosphere, a solution of bis(1 ,1-dimethylethyl) (E)- 1 ,2-diazenedicarboxylate (DBAD) (1.59 g, 6.92 mmol) in THF (2.4 ml) was added. After 5 min the ice-bath was removed and the reaction mixture was stirred at RT. After 2h additional amount of 1 ,1-dimethylethyl 4-hydroxy-i-piperidinecarboxylate (150 mg), TPP (160 mg) and DBAD (140 mg) were added and the reaction mixture was stirred overnight. The reaction mixture was concentrated under vacuum and the residue was purified by FC on silica (eluting with Cy/EA from 1/0 to 7/3) to give 0.32 g of the title product .MS(m/z): 340.12 [MH]+.Following the above procedure, starting from ethyl 5-oxo-2,5-dihydro-1 H-pyrazole-3- carboxylate (0.8 g, 5.12 mmol) and 1 ,1-dimethylethyl 4-hydroxy-1-piperidinecarboxylate (1.65 g, 8.20 mmol) a further amount of the title compound (0.49 g) was prepared.MS(m/z): 340.12 [MH]+.

The chemical industry reduces the impact on the environment during synthesis Ethyl 5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/130232; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics