Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 191980-54-8, name is 4-Iodo-1-trityl-1H-pyrazole, A new synthetic method of this compound is introduced below., name: 4-Iodo-1-trityl-1H-pyrazole
Compound 36b (79 mg, 0.181 mmol),Compound 36c (50 mg, 0.151 mmol),K2CO3 (52mg, 0.378mmol),(1R,2R)-(-)-N,N’-Dimethyl-1,2-cyclohexanediamine (17mg, 0.121mmol)And CuI (6mg, 0.03mmol) was dissolved in 5mL dioxane,Protected with nitrogen, stirred at 90 C overnight, filtered,The filtrate was concentrated and purified by silica gel column chromatography to give compound 36d.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Zhu Jiawang; Cai Jiaqiang; Li Guiying; You Zejin; Wu Yongyong; Han Runfeng; Ge Yong; Wang Lichun; Wang Jingyi; (49 pag.)CN109928979; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics