Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27511-79-1, name is 3-Amino-1H-pyrazole-4-carboxamide sulfate(2:1), This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H14N8O6S
This embodiment relates to a process for synthesizing a pyrazolo [3,4-d] pyrimidine compound, which comprises the following steps:Step one, 15 g of 3-aminopyrazole-4-carboxamide hemisulfateAnd 150g of formamide (molar ratio of 1:10) was added to a 100mL three-necked round bottom flask, first with hydrochloric acid to adjust the pH to 2.6, and then warmed to 115 , and stirred at this temperature for 12h at room temperature, the reaction mixture First clear as a clear solution and then gradually precipitated a white solid, the reaction was cooled to room temperature after the reaction;Step two, the product obtained in step one was placed in the range of 7 12h,Let the product fully crystallized from formamide solution;Step three, the filter, the filtrate recovery applied, the resulting crystal crude beaker into the beater by mass than the crude product: purified water ratio of 1:14 by adding purified water, beating washing 3 hours;Step four, filtered again, the filtrate was discarded, the filter cake was washed with purified water until the eluate pH ? 6, after drying to obtain a white 4-hydroxypyrazolo [3,4-d] pyrimidine, the state is white Crystal powder, molar yield of 92.1%, purity of 99.8%
According to the analysis of related databases, 27511-79-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shanghai Titan Technology Co., Ltd.; Xie Yingbo; Zhang Qing; Zhang Hua; Xu Xiaobing; Zhang Weiyan; Luo Guiyun; (6 pag.)CN104447758; (2017); B;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics