Some common heterocyclic compound, 947763-34-0, name is 1-Ethyl-3-methyl-1H-pyrazol-4-amine, molecular formula is C6H11N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 947763-34-0
To a solution of 2,4-dichloro-1,3,5-triazine (330 mg, 2.2 mmol) in dichloromethane (15 mL) at 0 C., 1-ethyl-3-methyl-1H-pyrazol-4-amine (250.34 mg, 2 mmol) was added, followed by N,N-Diisopropylethylamine (0.523 mL, 3 mmol). The reaction mixture was stirred at 0 C. for 40 minutes. After this time, the reaction was quenched with saturated sodium bicarbonate solution (PH?8) and extracted with dichloromethane for three times. The combined extracts were washed once with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The crude residue was purified by flash chromatography (silica gel) to give the desired product as red solid. LCMS-ESI+ (m/z): [M+H]+ calcd for C9H12ClN6: 239.7. found: 239.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 947763-34-0, its application will become more common.
Reference:
Patent; Gilead Sciences, Inc.; Du, Zhimin; Guerrero, Juan A.; Kaplan, Joshua A.; Knox, JR., John E.; Lo, Jennifer R.; Mitchell, Scott A.; Naduthambi, Devan; Phillips, Barton W.; Venkataramani, Chandrasekar; Wang, Peiyuan; Watkins, William J.; Zhao, Zhongdong; (593 pag.)US2016/96827; (2016); A1;,
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