Synthetic Route of 70817-26-4, These common heterocyclic compound, 70817-26-4, name is (1-Phenyl-1H-pyrazol-4-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4) Will be 1.74 g (0.01 muM) 1 – phenyl -4 – hydroxymethyl pyrazole, in 100 ml of the single port in the bottle, by adding 35 ml dichloromethane, stirring in ice bath, dripping 1.43 g (0.012 muM) of thionyl chloride, device end gas collecting device, TLC monitoring after the reaction, reducing pressure and solvent, adding (3 × 50 ml) ethyl acetate extraction, the organic phase with saturated salt water 50 ml washing, desolvation residue after column chromatography (eluting agent is ethyl acetate with petroleum ether (reflux 60 – 90 C), the volume ratio of 1:4) shall be 1.55 g brown solid, yield 81.0%.
The synthetic route of 70817-26-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shenyang Sinochem Pesticide Chemical Research And Development Co., Ltd.; Liu Changling; Guan Aiying; Sun Qin; Yang Jinlong; Li Zhinian; Sun Xufeng; Xia Xiaoli; Ma Sen; Yang Fan; (63 pag.)CN107964007; (2018); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics