In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27412-71-1, name is 5-Phenyl-1H-pyrazol-3(2H)-one belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 27412-71-1
Synthesis of 5-Phenyl-1H-pyrazol-3-yl 1-(2,2,2-trifluoroacetyl)indoline-5-sulfonate (8) and 5-phenyl-1H-pyrazol-3-yl indoline-5-sulfonate (9). Added anhydrous potassium carbonate (1.6 g, 12.5 mM) to a cold solution of 5-phenyl-1H-pyrazol-3(2H)-one (7,1 g, 6.25 mM) and (1-(2,2,2-trifluoroacetyl)indolin-5-ylsulfonyl chloride (2.0 g, 6.39 mM) in DMF and stirred the reaction mixture for 2 h at room temperature. After completion of the reaction was confirmed by TLC, the reaction mixture was mixed with ice cold water and extracted with ethyl acetate. Organic layer was dehydrated with anhydrous sodium sulfate and evaporated under reduced pressure. The crude solid was subjected to column chromatography to separate 8 and 9.
The synthetic route of 27412-71-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Subramanian, Santhosh; Sharma, Vinay K.; Yun, Jieun; Jung, Sang-Hun; Bulletin of the Korean Chemical Society; vol. 35; 10; (2014); p. 2922 – 2928;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics