Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 86-92-0, name is 3-Methyl-1-p-tolyl-5-pyrazolone, A new synthetic method of this compound is introduced below., Computed Properties of C11H12N2O
General procedure: A mixture containing 4-fluorophenylhydrazine hydrochloride or 4-bromophenylhydrazinehydrochloride (4.47 mmol), ethyl acetoacetate (565 uL, 4.47 mmol) and 2.0mL of acetic acid was reflux for 8 h. The solution was then cooled to ambienttemperature and concentrated in vacuo. The crude product was purified by silica gelflash chromatography (PE/EA = 3/1, v/v) to afford 1-aryl-3-methyl-1H-pyrazol-5(4H)-one. Then 2.0 mmol 1-aryl-3-methyl-1H-pyrazol-5(4H)-one (R = 4-F, 4-Cl,4-Br, 4-CH3, 4-CH3O) was reacted with iodomethane (6 mmol) and acetonitrile (4 mL)in the dark in a sealed tube maintained at 120 in an oil bath. After 17 h, themixture was cooled to room temperature. The solvent was then evaporated in vacuo,and the resulted residue was purified by flash column chromatography (ethyl acetate)to yield 2t-2x.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
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