These common heterocyclic compound, 70817-26-4, name is (1-Phenyl-1H-pyrazol-4-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 70817-26-4
Example 14: (R)-3-(l-Phenyl-cycloheptanecarbonyloxy)-l-(l-phenyl-lH-pyrazol-4- ylmethyl)-l-azonia-bicyclo[2.2.2]octane chloridea) 4-Chloromethyl- 1 -phenyl- lH-pyrazole (1 -Phenyl- lH-pyrazol-4-yl)-methanol (2 g) in dichloromethane (15 mL) was treated with thionyl chloride (10 mL) and the mixture stirred at 200C for 1 h. The resulting suspension was diluted with z’s°hexane (15 mL) and the solid collected by filtration (1.12 g).1H NMR (399.826 MHz, DMSO-D6) delta 8.61 (s, IH), 7.84 – 7.80 (m, 3H), 7.53 – 7.47 (m, 2H), 7.35 – 7.30 (m, IH), 4.77 (s, 2H).
The synthetic route of (1-Phenyl-1H-pyrazol-4-yl)methanol has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ARGENTA DISCOVERY Ltd.; FORD, Rhonan; WO2009/139709; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics