Some common heterocyclic compound, 575452-22-1, name is 1-(1-Ethoxyethyl)-4-iodo-1H-pyrazole, molecular formula is C7H11IN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H11IN2O
General procedure: To a suspension of magnesium (1.3 equiv) in THF (for 1 mol of magnesium 700 mL of THF wereused), at the boiling temperature under argon atmosphere, ethyl bromide (1.4 equiv) was addeddropwise and left to stir at same temperature for one hour. Then the reaction mixture was cooleddown to given temperature and solution of starting pyrazole derivative 2a, 3a or 6a (1 equiv) inTHF (for 1 mol of pyrazole 350 mL of THF were used) was added dropwise at same temperature.After 1 hour of stirring at the same temperature dimethylformamide (1.5 equiv) was added to thereaction mixture dropwise and left to warm to room temperature overnight. Then saturated NH4Cl(5 equiv) solution in deionized water were added to the reaction mixture, organic layer wasseparated and NH4Cl solution was extracted with dichloromethane (for 1 mol of pyrazole 0.5 L ofdichloromethane were used) twice. Organic layers were combined, washed with deionized water(for 1 mol of pyrazole 0.5 L of water were used), dried with anhydrous Na2SO4 and evaporatedunder reduced pressure. Products were purified by distillation or column chromatography.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 575452-22-1, its application will become more common.
Reference:
Article; Mazeikaite, Rita; Sudzius, Jurgis; Urbelis, Gintaras; Labanauskas, Linas; ARKIVOC; vol. 2014; 6; (2014); p. 54 – 71;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics