These common heterocyclic compound, 19959-77-4, name is 2-(5-Methyl-1H-pyrazol-3-yl)pyridine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine
Complex 3 could be obtained by two methods:Method 1: using the diffusion method as for the above mentionedcompounds; solid HL (14.5 mg, 0.10 mmol) and Cu(CH3-COO)2H2O (19.9 mg, 0.10 mmol) were separated into two armsof an H-tube, which was filled with acetonitrile as the solvent system.Two weeks later, black-green block crystals of compound 3were obtained.Method 2: using the solvothermal method; HL (15.9 mg,0.10 mmol) and Cu(CH3COO)2H2O (19.9 mg, 0.10 mmol) were dissolvedin acetone (10 mL), to which NEt3 (14 muL, 0.1 mmol) wasadded dropwise under stirring. The resultant green solution wascontinuously stirred for an additional 10 min, then transferred intoa 25 mL Teflon-lined autoclave and heated at 140 C for 3 days. Theresultant clear solution was filtered, then left to evaporate for threedays to give black-green block crystals of 3. The crystals werewashed with n-hexane 2 3 times, then dried in a vacuum. Yield:26.9 mg (48%), M.p. >300 C. Anal. Calc. for C22H22N6O4Cu2 (FW,561.54): C, 47.06; H, 3.95; N, 14.97. Found: C, 47.34; H, 3.89; N,14.71%. Selected IR data (cm-1, KBr): 3422 (br); 2926 (w); 1611(s) (m(CN)); 1584 (s) (m(CC)); 1497 (w); 1462 (s) (d(CH3));1391 (w); 1335 (s); 1184 (w); 1050 (w); 988 (w); 779 (s); 749(w); 683 (m); 620 (w) (see Scheme 2).
The synthetic route of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yang, Feng-Lei; Zhu, Guang-Zhou; Liang, Bei-Bei; Shi, Yan-Hui; Li, Xiu-Ling; Polyhedron; vol. 128; (2017); p. 104 – 111;,
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