Application of 2654-57-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2654-57-1, name is 4-Methyl-1-phenylpyrazolidin-3-one belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
(a) 3-hydroxy-4-methyl-1-(4-nitro-phenyl)-1H-pyrazole 8.00 g (45.4 mmol) 4-methyl-1-phenyl-1H-pyrazolidin-3-one are added to 80 ml conc. sulphuric acid at -5 C. with stirring and stirred for another 5 min. Then 3.8 ml (54.5 mmol) 65% nitric acid are added with cooling such that the temperature remains between -15 and -10 C. The reaction mixture is stirred for 1 h between -20 and -5 C., then poured into ice water and suction filtered. The filter cake is washed with water, dried at 55 C. and further reacted without any further purification. Yield: 8.00 g (approx. 40%), approx. 50% C10H9N3O3 (219.20) Rf value: 0.70 (silica gel; cyclohexane/ethyl acetate=1:1)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methyl-1-phenylpyrazolidin-3-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Dahmann, Georg; Gerlach, Kai; Pfau, Roland; Priepke, Henning; Wienen, Wolfgang; Schuler-Metz, Annette; Nar, Herbert; US2008/51578; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics