Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1072-91-9, name is 1,3,5-Trimethylpyrazole, A new synthetic method of this compound is introduced below., Recommanded Product: 1,3,5-Trimethylpyrazole
1,3, 5-Trimethyl-lH-pyrazole (630 mg, 5.71 mmol) cooled to [0 oC] was treated with oxalyl chloride (7.0 mL). The reaction was then warmed to [25 oC] and then heated to reflux for 4 h. At this time, the reaction was cooled to [25 oC] and was stirred at [25 oC] for 24 h. At this time, the excess oxalyl chloride was removed by distillation. The resulting residue was cooled to [0 oC] and treated with ice/water (15 mL). The mixture was slowly warmed to [25 oC] over 4 h. At this time, the resulting solids were collected by filtration, washed with water, and dried in vacuo to afford [OXO- (1,] 3,5- [TRIMETHYL-LH-PYRAZOL-4-YL)-ACETIC] acid (700 mg, 70%) as brown solid
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2003/106459; (2003); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics