Application of 1239726-11-4,Some common heterocyclic compound, 1239726-11-4, name is 1-(2-Fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid, molecular formula is C11H9FN2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Synthesis example 9Ethyl (S)-3-{[1 -(2-fluoro-phenyl)-5-methoxy-1 H-pyrazole-3-carbonyl]-amino}-3-(2- methyl-phenyl)-propionate Step 1 : 1 -(2-Fluoro-phenyl)-5-methoxy-1 H-pyrazole-3-carbonyl chlorideA suspension of 1 -(2-fluoro-phenyl)-5-methoxy-1 H-pyrazole-3-carboxylic acid (39.1 g, 167 mmol) in 2-methyltetrahydrofuran (300 ml) was cooled to 0 C and DMF (293 muIota, 3.81 mmol) was added. Oxalyl chloride (23.1 g, 182 mmol) was added dropwise. After 16 h at room temperature ca. 100 ml of the solvent were removed by distillation. The resulting suspension of the title compound was used directly in the next step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(2-Fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid, its application will become more common.
Reference:
Patent; SANOFI; RUF, Sven; PERNERSTORFER, Josef; SADOWSKI, Thorsten; HORSTICK, Georg; SCHREUDER, Herman; BUNING, Christian; OLPP, Thomas; SCHEIPER, Bodo; WIRTH, Klaus; WO2011/92187; (2011); A1;,
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