The important role of C10H9BrN2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 73387-52-7, name is 5-(4-Bromophenyl)-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Recommanded Product: 73387-52-7

5-(4-bromophenyl)-1 -methyl-1 H-pyrazole (7.84 g), sodium te/f-butoxide (3.81 g), 1 ,1 ‘-bus(di-i-propylphosphino)ferrocene (332 mg), and palladium acetate (148 mg ) were placed under nitrogen and combined with 60 ml_ anhydrous 1 ,4-dioxane. The resulting mixture was stirred at room temperature for 1 hour before adding thisopropylsilanethiol (7.81 ml) followed by heating at reflux for 1 hour. After cooling to room temperature, the mixture was diluted with ethyl acetate and washed with water twice and 5% aqueous sodium chloride once. The organic layer was dried over sodium sulfate, filtered, concentrated, and purified by flash chromatography on silica gel to give the title compound. LCMS (M+H): 347; 1 H NMR (400 MHz, DMSO-c/6) delta ppm 0.85- 0.96 (m, 3 H) 0.96 – 1.02 (m, 18 H) 3.84 (s, 3 H) 7.40 (s, 1 H) 7.46 (s, 1 H) 7.58 (d, J=8.32 Hz, 2 H) 7.63 – 7.71 (m, 2 H).

The synthetic route of 73387-52-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; WO2009/69044; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics