Electric Literature of 143426-49-7, A common heterocyclic compound, 143426-49-7, name is (4-Pyrazol-1-yl-phenyl)methanol, molecular formula is C10H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 4 N-[1-(6-{[4-(1H-pyrazol-1-yl)benzyl]oxy}-1-benzofuran-3-yl)ethyl]acetamide To a solution of N-[1-(6-hydroxy-1-benzofuran-3-yl)ethyl]acetamide (35.0 mg, 0.160 mmol) obtained in Reference Example 4 in THF (5 mL) were added [4-(1H-pyrazol-1-yl)phenyl]methanol (41.8 mg, 0.240 mmol), triphenylphosphine (63.0 mg, 0.240 mmol) and 2.2 M diethyl azodicarboxylate toluene solution (0.110 mL, 0.240 mmol), and the mixture was stirred at room temperature for 30 min. The solvent was evaporated under reduced pressure and the obtained residue was purified by preparative HPLC to give the title compound (29.4 mg, yield 33%) as a white solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2351743; (2011); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics