Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 796729-03-8, name is 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid, A new synthetic method of this compound is introduced below., Safety of 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid
Add 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid (1.60 g, 10.5 mmol) and 30 mL of 1,4-dioxane, benzyl alcohol to a 50 mL vial (1.64 mL, 15.8 mmol), DIPEA (3.5 mL, 21.0 mmol),And DPPA (4.35g, 15.8mmol), reacted at 105 C for 3h, the reaction was completed by TLC, directly spin-drying silica gel column chromatography, eluting with PE / EA = 2 / 1 to obtain 0.35g white solid, yield 13 %,
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Lin Xinglong; Xie Hongming; Hu Yangxiao; Li Shiguang; Zhang Yingjun; Tan Yumei; Yuan Mingyun; (124 pag.)CN108948019; (2018); A;,
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