Reference of 1239363-40-6, The chemical industry reduces the impact on the environment during synthesis 1239363-40-6, name is 1-Cyclopropyl-4-iodo-1H-pyrazole, I believe this compound will play a more active role in future production and life.
Into a dry microwave vial with stir bar was added intermediate 15.2 (200 mg, 0.625 mmol), potassium phosphate tribasic (398 mg, 1.876 mmol), (Irans)-N 1 N2-dimethylcyclohe xane-l, 2-diamine (44.5 mg, 0.313 mmol), l-cyclopropyl-4-iodo-lH-pyraz ole (293 mg, 1.251 mmol), and copper(I) iodide (35.7 mg, 0.188 mmol). The vial was sealed and purged with nitrogen. Then, DMSO (3.5 mL) was added and the solution was heated to 80C overnight. The next day, the crude material was filtered through a plug of Celite (diatomaceous earth) using EtOAc. The filtrate was concentrated and purified by reverse phase prep-HPLC (Method A) to afford intermediate 15.3, (R and S)-5-chloro-l-(l -cyclopropyl- lH-pyrazol-4-yl)-6- (l-(3-methyltetrahydrofuran-3-yl)piperidin-4-yl)-lH-indazole, TFA salt. MS (ESI) m/z calc?d for C23H28CIN5O [M+H]+ 426, found 426.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Cyclopropyl-4-iodo-1H-pyrazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; SIMOV, Vladimir; KAPLAN, William, P.; ACTON, John, J., III; ARDOLINO, Michael, J.; CHEN, Joanna, L.; FULLER, Peter, H.; GUNAYDIN, Hakan; LI, Derun; LIU, Ping; LOGAN, Kaitlyn Marie; METHOT, Joey; MORRIELLO, Gregori, J.; NEELAMKAVIL, Santhosh, F.; TORRES, Luis; YAN, Xin; ZHOU, Hua; (0 pag.)WO2020/92136; (2020); A1;,
Pyrazole – Wikipedia,
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