Some common heterocyclic compound, 150712-24-6, name is 5-Benzyl-1H-pyrazol-3-amine, molecular formula is C10H11N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 150712-24-6
The solution of 2, 4,5-trichloropyrimidine (0.150 g, 0.82 mmol), 5-benzyl-2H-pyrazol- 3-ylamine (Method 27; 0.129 g, 0.74 mmol), and triethylamine (0.155 ml, 1.12 mmol) in EtOH (5 ml) was heated to55 C for 5 hours and then stirred at room temperature overnight. The reaction solution was concentrated under reduced pressure. The resulted yellow solid was stirred in hexanes: ether solution (1: 1), collected by filtration, and then recrystallized from DCM to give the title compound (0.212 g,89%).’H NMR (400 MHz, CDC13)6 4.10 (d, J= 15.2 Hz, 2 H), 6.89 (s, 1 H), 7.27-7. 37(m, 5 H), 8. 28 (s, 1 H). MS: Calcd.: 319; Found:[M+H] + 320
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 150712-24-6, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/49033; (2005); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics