Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 90253-21-7, name is 4-Cyclopropyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., name: 4-Cyclopropyl-1H-pyrazole
Preparation 23b: {3-[4-(4-cyclopropylpyrazol-1 -yl)benzyl]-4-difluoromethoxy-2-ethyl- 8-fluoroquinolin-5-yloxy}acetic acid methyl ester; A mixture of (4-{[4-difluoromethoxy-2-ethyl-8-fluoro-5-(2-methoxy-2-oxoethoxy) quinolin-3-yl]methyl}phenyl)boronic acid (0.1 g), 4-cyclopropyl-1 H-pyrazole (0.047 g), cuprous acetate (0.078 g) and pyridine (3 ml_) was heated at 40 0C for 24 hours. The mixture was cooled to room temperature, diluted with water (10 mL) and extracted with ethyl acetate. The combined extracts were washed with saturated aqueous sodium chloride solution, dried over magnesium sulphate and then concentrated under reduced pressure. Purification of the residue by column chromatography on silica gel, eluting with a mixture of cyclohexane and ethyl acetate (1 :0 to 7:3 by volume) gave title compound as pale green oil (0.09 g).MS: ESI (+ve) (Method B): 526 (M+H)+, Retention time 4.5 min
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 90253-21-7.
Reference:
Patent; ARGENTA DISCOVERY LIMITED; WO2008/122784; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics