Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 796729-03-8, name is 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H8N2O2
Step (c) N-((ls,4s)-4-(2-(3′-(3-((3S,5R)-3,5-Dimethylpiperazin-l-yl)propyl)biphenyl-3- yloxy)-5-fluoronicotinamido)cyclohexyl)-5,6-dihydro-4H-pyrrolo[l,2-b]pyrazole-2- carboxamideTo a stirred solution of N-((ls,4s)-4-aminocyclohexyl)-2-(3′-(3-((3S,5R)-3,5- dimethylpiperazin- 1 -yl)propyl)biphenyl-3-yloxy)-5-fluoronicotinamide hydrochloride (0.180 g, 0.28 mmol) in acetonitrile (2 mL) was added 5,6-dihydro-4H-pyrrolo[l,2-b]pyrazole-2- carboxylic acid (0.052 g, 0.34 mmol) and triethylamine (0.397 mL, 2.85 mmol). The reaction mixture was stirred at RT for 10 min. 1-Propanephosphonic acid cyclic anhydride, 1.57M solution in THF (0.228 mL, 0.34 mmol) was added and the reaction mixture was stirred at RT under nitrogen for 2 h then concentrated to give crude product. The crude product was purified by preparative HPLC on a Waters X-Bridge column using a 70-20% gradient of
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/144494; (2009); A1;,
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