Electric Literature of 1239726-11-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1239726-11-4, name is 1-(2-Fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.
Synthesis example 174-Bromo-1 -(2-fluoro-phenyl)-5-methoxy-1 H-pyrazole-3-carboxylic acid 50 mg (0.21 mmol) of 1 -(2-fluoro-phenyl)-5-methoxy-1 H-pyrazole-3-carboxylic acid were dissolved in 1 .5 ml of acetic acid, sodium acetate (35 mg, 0.42 mmol) and bromine (50 mg, 0.21 mmol) were added and the mixture was stirred for 60 min. The solvent was removed in vacuo and the residue subjected to an aqueous work-up. The obtained crude title compound (60 mg) was used in the next step without further purification.
The chemical industry reduces the impact on the environment during synthesis 1-(2-Fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SANOFI; RUF, Sven; PERNERSTORFER, Josef; SADOWSKI, Thorsten; HORSTICK, Georg; SCHREUDER, Herman; BUNING, Christian; OLPP, Thomas; SCHEIPER, Bodo; WIRTH, Klaus; WO2011/92187; (2011); A1;,
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