Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1125828-30-9, name is 1-(4-Chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethanone, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-(4-Chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethanone
Step 3:A solution of dichloro (pentamethylcyclopentadienyl)iridium (III) dimer([Cp*IrCl2]2, CAS No. 12354-84-6, 3 mg), (1R,2R)-(-)-(4-toluenesulfonyl)-1,2-diphenylethylenediamine(CAS No. 144222-34-4, 2.5 mg), and water (12 mL) at room temperature. Theresulting mixture was heated to 40 oC for 3 h to give a homogeneousorange solution. To this active catalyst solution, and at the same temperature(40 oC), were added potassium formate anda solution of 1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethanone(5 g) in CH3CN. The reactionmixture was then stirred at 40 oC for 2 h. After cooling to 30 oC,the aqueous layer was removed. The organic layer was treated with activatedcharcoal (Darco G-60, 12g, CAS: 7440-44-0) at 45 oC for 2 h andfiltered through inch bed of Filter agent (CAS: 61790-53-2) and washed withCH3CN. The filtrate was concentrated to 150 mL. An additional amountof CH3CN (30 mL) was added to increase the solution volume to 180mL. This solution was warmed to 60 oC and water was added to thissolution at the same temperature. After stirring for 15 min at 60 oC,the resulting emulsion-like milky mixture was slowly cooled to room temperaturewith stirring. The crystals were then filtered at room temperature and washedwith CH3CN/water (1:2, 90 mL). The wet cake was dried under vacuumat 40 oC for 4 h to afford the title alcohol (44) as white solid (55g).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1125828-30-9.
Reference:
Article; Aiello, Robert; Barucci, Nicole; Bourassa, Patricia; Goldberg, Daniel R.; Paralkar, Vishwas; Valentine, James; Zavadoski, William; Zhang, Qing; De Lombaert, Stephane; Bioorganic and medicinal chemistry letters; vol. 26; 4; (2016); p. 1124 – 1129;,
Pyrazole – Wikipedia,
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