Reference of 1031351-95-7, The chemical industry reduces the impact on the environment during synthesis 1031351-95-7, name is Methyl 3-formyl-1-methyl-1H-pyrazole-5-carboxylate, I believe this compound will play a more active role in future production and life.
Preparation of hydroxylamine aqueous solution: Mix 3.13g hydroxylamine hydrochloride and 2.46g sodium acetate, Add 15mL water, The aqueous solution of hydroxylamine was prepared by stirring at room temperature. Dissolve 5.1 g (30 mmol) of 3-formyl-1-methyl-1H-pyrazole-5-carboxylic acid ethyl ester(I-1, R7=Me) (synthesized according to the reporting method of CN1278820) in 20 mL of THF, Add the prepared hydroxylamine aqueous solution dropwise at room temperature, and continue stirring for 2 hours after the drop . After complete reaction, THF was removed by desolvation, after adding water, filtering, washing with water and drying to obtain 4.95 g of white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-formyl-1-methyl-1H-pyrazole-5-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Zhejiang Chemical Institute Co., Ltd.; Sinochem Lantian Group Co., Ltd.; Peng Weili; Xing Jiahua; Li Jiao; Xu Tianming; Huang Hongying; Yu Jiping; (32 pag.)CN111362931; (2020); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics