Share a compound : 3-Iodo-1H-pyrazole

The synthetic route of 3-Iodo-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Application of 4522-35-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4522-35-4, name is 3-Iodo-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step 2: 3-iodo-l-methyl-lH-rhoyrazole.To a stirred solution of 3-iodo-leta-rhoyrazole (0.5 g, 2.6 mMol) in anhydrous DMF (5.0 mL) was added iodor¡ãethane (3.7 g, 25.8 mMol). The resulting solution was cooled to 00C, and NaH (0.11 g, 2.8 EPO mMol, 60% dispersion in mineral oil) was added. The reaction mixture was allowed to warm to ambient temperature, and was stirred for 15 minutes. Water (20 mL) was added, and the resulting solution was extracted with EtOAc (1 x 30 mL). The organic layer was washed with water (2 x 30 mL), and brine (1 x 30 mL). The organic layer was dried over magnesium sulfate, filtered, and concentrated to afford the title compound. LRMS (ESI) calculated for C4H5IN2 [M+H]+, 208.9; found 209.0.

The synthetic route of 3-Iodo-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2007/35309; (2007); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics