Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 938066-17-2, name is 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole, A new synthetic method of this compound is introduced below., COA of Formula: C8H11IN2O
(2) 27.8 g of the intermediate 4-bromo-1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazole obtained in (1) was dissolved in 200 ml of THF,Cool to minus 75 degrees,48 ml (0.12 mol) of n-butyl lithium solution with a concentration of 2.5 mol / L was added dropwise,Maintain the temperature around minus 75 degrees,After dropping, keep warm for half an hour,Subsequently, 8.8 g (0.12 mol) of N, N-dimethylformamide is added at this temperature, and the reaction formula of step (2) is as follows:After the reaction is completed, naturally warm to room temperature,Add dilute hydrochloric acid to quench until the system pH is less than 1, stir at room temperature for 3-4 hours, neutralize with sodium bicarbonate, and extract with ethyl acetate.After drying and concentration, it was purified by silica gel short column adsorption to obtain the target product 4-formylpyrazole 7.2 g.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Changsha Luxing Biological Technology Co., Ltd.; Tan Yongjun; Yang Bing; Zhu Zhiping; Zhang Jianhua; (10 pag.)CN110734401; (2020); A;,
Pyrazole – Wikipedia,
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