Reference of 1202993-11-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1202993-11-0 as follows.
3.2 g of 5-chloro-3-(difluoromethyl)-1 -methyl-1 H-pyrazole-4-carboxylic acid and 44.3 mL of thionyl chloride are refluxed for 5 hours. After cooling down, the reaction mixture is evaporated under vacuum to yield 3.5 g of 5-chloro-3-(difluoromethyl)-1 -methyl-1 H-pyrazole-4-carbonyl chloride as a yellow oil. H NMR (400 MHz, CHCI3-c/6) delta ppm : 3.97 (s, 3H); 7.00 (t, J = 52.01 Hz, 1 H); IR (TQ) : 1759 and 1725 cm”1 (C=0).
According to the analysis of related databases, 1202993-11-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER CROPSCIENCE AG; BENTING, Juergen; CRISTAU, Pierre; DAHMEN, Peter; DESBORDES, Philippe; GARY, Stephanie; SCHMIDT, Jan-Peter; WACHENDORFF-NEUMANN, Ulrike; WO2012/59497; (2012); A1;,
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