Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35277-02-2, name is 4-Fluoro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., name: 4-Fluoro-1H-pyrazole
7-Bromo-5 -(chloromethyl)-2,3 -dihydro- 1 -benzofuran 3 (120 mg, 0.48 mmol, 1.17 eq.), 4-fluoro-JH-pyrazole (35 mg, 0.41 mmol, leq.), K2C03 (120 mg, 0.87 mmol, 2.1 eq.) in DMF (1 mL) were stirred at rt for 18 hr. The reaction was diluted with water (8 mL) and extracted with EtOAc (10 mL X 2). The combined organics were dried over Na2SO4, and concentrated to give a residue, which was purified by chromatography (SG, hexane/DCM (1.5:1)) to yield 4 as a white solid (106 mg, 88% yield).
According to the analysis of related databases, 35277-02-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TETRA DISCOVERY PARTNERS, LLC; NUGENT, Richard A.; GURNEY, Mark; MO, Xuesheng; (92 pag.)WO2016/49595; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics