Related Products of 2075-46-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2075-46-9 as follows.
Sodium hydride (1.3 g, 32.1 mmol) was added to a solution of 4-nitropyrazole (3.3 g, 29.2 mmol) in dry tetrahydrofuran (30 mL) at 0 C. After stirring for 1 hour, methyl iodide (20 mL) was added and the mixture was stirred for another 2 hours at room temperature. The mixture was poured into ice water (100 mL) and extracted with ethyl acetate (50 mL*3). The organic phase was dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. The residue was added to a mixed solvent (20 mL) of petroleum ether and ethyl acetate (20:1), and stirred, solid was precipitated out. The solid was filtered out and dried in vacuo for 8 hours to give 1-f as a white solid (2.6 g, yield 70%). The product was directly used in the next reaction without further purification. LC-MS (ESI): m/z=128[M+H]+.
According to the analysis of related databases, 2075-46-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.; XU, Zusheng; ZHANG, Nong; WANG, Tinghan; SUN, Qingrui; WANG, Yuguang; (90 pag.)US2018/208604; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics