In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1203705-55-8, name is 3-Bromo-1H-pyrazol-5-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C3H4BrN3
1.0 g of compound II was dissolved in 15 mL of acetic acid, and 0.61 g of 3-bromo-1H-pyrazole-5-amine was added to the above solution, heated under reflux, and monitored by thin layer chromatography. After the reaction was completed, the mixture was extracted with ethyl acetate-water. The ethyl acetate layer was dried over anhydrous sodium sulfate, and the solution was concentrated. Column chromatography of dichloromethane-methanol 100: 3 gave 1.25 g of compound III. Yield: 91.1%.
The synthetic route of 1203705-55-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Southern Medical University; Chen Jianjun; Li Gang; Deng Xin; Ren Yichang; Li Ling; (23 pag.)CN110563732; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics