Reference of 73387-52-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73387-52-7, name is 5-(4-Bromophenyl)-1-methyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.
In a 40 ml vial, bromo derivative (236 mg, 1.06 mmol, 1.0 eq.), bispinacolotodiboron (253.6 mg, 1.06 mmol, 1.0 eq.), Pd(dppf)CI2 (86.4 mg, 0.106 mmol, 0.1 eq.) and potassium acetate (321.8 mg, 3.17mmol, 3.0 eq.) were mixed in dioxane (10 ml) and heated to 80 C for 48 hours. LCMS indicated that the product was formed in major amount. . The crude reaction was purified in the presence of silica (10-15 gm) and purified using hexanes: ethyl acetate (0-100%) to yield desired boron ester. Theproduct was characterized by reverse phase HPLC using method 4. (ES, m/z) [M +H+] 284.9. Retention time = 1.42 mins
The chemical industry reduces the impact on the environment during synthesis 5-(4-Bromophenyl)-1-methyl-1H-pyrazole. I believe this compound will play a more active role in future production and life.