Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18213-75-7, name is 5-Amino-1-methyl-1H-pyrazole-4-carboxamide, A new synthetic method of this compound is introduced below., SDS of cas: 18213-75-7
To 5 -amino- 1 -methyl- lH-pyrazole-4-carboxamide (2 g, 14.3 mmol) and sodium 2,2-difluoro-2-(5-fluoropyridin-2-yl)acetate (3.64 g, 17.12 mmol) was added trimethylsilyl polyphosphate (20 mL) and the mixture was heated at 130 C overnight. The solution was cooled, equal volumes of EtOAc and water were added, and the mixture was stirred for 30 min. The organic layer was washed with brine, separated, dried over Na2S04, filtered, and concentrated under reduced pressure. The residue was dissolved in DCM and extracted with 1 N aqueous NaOH. The aqueous layer was washed with DCM and then acidified with 4 N HC1 and extracted with EtOAc. The organic layer was separated, dried over Na2S04, filtered, and concentrated under reduced pressure to afford 6-(difluoro(5-fluoropyridin-2- yl)methyl)-l -methyl- lH-pyrazolo[3,4-d]pyrimidin-4-ol (1.85 g, 44%) as a solid, which was used without further purification. H NMR (300 MHz, DMSO-t 6) delta 11.67 (s, 1H), 8.77 (s, 1H), 7.95 – 8.21 (m, 3H), 3.74 (s, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.