Reference of 35344-95-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To the stirred solution of tert-butyl 2, 6-dimethyl -4-methylsulfonyloxy-piperi dine- 1 – carboxylate 24-2 (400.0 mg, 1.30 mmol) in DMF (3.5 mL) was added cesium carbonate (847.92 mg, 2.60 mmol) and lH-pyrazole-4-carbaldehyde 3 (125.03 mg, 1.30 mmol). The reaction mixture was heated at 70C for 16 hours. The reaction mixture was diluted with ethyl acetate, water and brine solution. The organic fraction was separated, dried over anhydrous sodium sulphate and evaporated under reduced pressure to obtain the crude compound purified by flash chromatography using (0-30 % ethyl acetate-hexane) to afford tert-butyl 4-(4-formylpyrazol-l- yl)-2, 6-dimethyl-piperidine- 1 -carboxylate 24-4 (200.0 mg, 650.65 umol, 50.00% yield) as off white solid. LC MS: ES+ 308.3.
The synthetic route of 1H-Pyrazole-4-carbaldehyde has been constantly updated, and we look forward to future research findings.