Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1227611-94-0, name is 4-(4-Iodo-1H-pyrazol-1-yl)cyclohexanone, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C9H11IN2O
A solution of 4-(4-iodo-1 H-pyrazol-1-yl)cyclohexanone 14 (200 mg, 0.69 mmol) in DCM (2 mL) was treated with methylamine hydrochloride (56 mg, 0.83 mmol) and AcOH (0.09 mL, 1.52 mmoi) and stirred at rt for 0.5h. Then sodium triacetoxyborohydride (321 mg, 1.52 mmol) was added and the reaction stirred at rt for a further 18h. It was then basified with 1 M sodium hydroxide solution (~ 7 mL) and extracted with DCM (4 x 10 mL). The combined organic extracts were dried (MgS04) and evaporated in vacuo to give the crude product. This was dissolved in dioxane (5 mL) and treated with TEA (0.38 mL, 2.76 mmol) and di- tertb-utyldicarbonate (264 mg, 1.38 mmol) and stirred at rt for 18h. Concentration in vacuo and column chromatography (2 – 100% EtOAc / pet ether gradient) gave 15 (121 mg, 43% over 2 steps) as a colourless oil and an inseparable mixture of cis- and trans- isomers; 1H NMR (400 MHz, CD3OD) delta ppm 7.91 (s, 1 H, isomer A), 7.81 (s, 1 H, isomer B), 7.55 (s, 1 H, isomer A), 7.51 (s, 1 H, isomer B), 4.40 – 4.36 (m, 1 H, isomer A), 4.24 – 4.18 (m, 1 H, isomer B), 4.03 – 3.92 (m, 1 H isomer A and 1 H isomer B), 2.80 (s, 3H, isomer B), 2.69 (s, 3H, isomer A), 2.58 – 2.51 (m, 2H, isomer A), 2.19 – 2.14 (m, 2H, isomer B), 2.10 – 1.88 and 1.83 – 1.74 (total 4H isomer A and 4H isomer B), 1.59 – 1.50 (total 2H isomer A and 2H isomer B), 1.50 (s, 9H, isomer A), 1.47 (s, 9H, isomer B); LCMS (m/z): 406 [M+H]+.
According to the analysis of related databases, 1227611-94-0, the application of this compound in the production field has become more and more popular.