Reference of 473528-88-0,Some common heterocyclic compound, 473528-88-0, name is 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde, molecular formula is C5H5BrN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 8-1 (700 mg, 3.7 mmol), bis(pinacolato)diboron (1.1 g, 4.4 mmol), Pd(dppf)Cl2 (190 mg, 0.26 mmol) and AcOK (1.1 g, 11.1 mmol) in dioxane (25 mL) was stirred at 105 C overnight under nitrogen atmosphere. After cooling to room temperature, the mixture was evaporated to remove most of dioxane. The residue was treated with brine (30 mL) and extracted with EtOAc (40 mL*2). The combined organic layers were dried over Na2SO4 and filtered. The filtrated was concentrated to give the crude title compound as a black oil (2.9 g).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde, its application will become more common.