Application of 39806-90-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39806-90-1 name is 4-Iodo-1-methyl-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 4-iodo-l-methyl-lH-pyrazole (10.20 mg, 0.049 mmol) in anhydrous DMSO (5 ml) was added common intermediate D.2 (10 mg, 0.033 mmol), (Irans)-N I N2- dimethylcyclohexane-l, 2-diamine (0.930 mg, 6.54 mhio). potassium phosphate (20.82 mg, 0.098 mmol) and Cul (0.623 mg, 3.27 pmol). The resulting mixture was stirred at 90C under N2 atmosphere for 12 hours. LCMS showed the starting material was consumed. After filtration and concentration, the crude product was purified by pre-HPLC (TFA) to give example 7.1, 5-chloro- l-(l-methyl-lH-pyrazol-4-yl)-6-(l-(3-methyloxetan-3-yl)piperidin-4-yl)-lH-indazole, TFA salt. MS (ESI) m/z calc?d for C20H25CIN5O [M+H]+ 386, found 386. NMR (400 MHz, CD3OD) d 8.15 (s, 1H), 8.13 (s, 1H), 7.94 (s, 1H), 7.86 (s, 1H), 7.50 (s, 1H), 4.92 (m, 3H), 4.49 (d, J = 7.83 Hz, 2H), 4.01 (s, 3H), 3.52-3.66 (m, 1H), 3.38-3.48 (m, 3H), 3.33 (br s, 1H), 2.30 (m, 2H), 2.08- 2.18 (m, 2H), 1.79 (s, 3H). LRRK2 ICso 1.4 nM.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Iodo-1-methyl-1H-pyrazole, and friends who are interested can also refer to it.